Say you suffer from a rare blood or bone marrow disease or something and need regular blood transfusions to stay alive.
Or invite them in and begin to freak them out but don't let them leave. Make sure they're aware that they've "got a purty mouth" and ask what their views on sodomy are.
I really can't think of many. Final Fantasy VIII and X are pretty much centered around love stories. Shadow of the Colossus is a good example of someone going through a lot for the one they love but there isn't any interaction in the game between Wander and Mono. I was about to suggest Snake and...
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