I once played a really old game about Donald Duck I think, at one part you gotta defeat a huge guy and jump onto his belly to get onto a ladder you can't reach otherwise. Once I jumped onto him, my character just dissapeared but I could see his shadow on the floor, so I guessed he was invisible...
I'd say speargun/telekinesis combo from BioShock2. It insta-kills pretty much everything with 1 headshot even on hard, and if it doesn't just shoot the same spear into the enemy again using telekinesis (or throw their own grenades at them).
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