Also let's not forget that the Brotherhood, the Enclave, and the Outcasts would all probably pull together in the event of a full scale invasion. In addition to this I imagine that there are some Enclave/BoS equivalents in other countries, China, Russia, etc. that survived the Great War.
If ALL of the Enclave and Brotherhood forces managed to put aside their differences and gather in one of the Brotherhood bunkers I imagine that they could put up a good fight. They would be able to hold of the Zerg for sure. Everything else would just fuck them over.
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