Being not much of a portable gamer these days, I like it. Bigger screen means you can see what's going on a bit better (although, granted, the resolution is the same).
I think this'll be great for Grandma/pa (or just people with worse eye-sight), but to be honest I don't think I'd ever buy one. What with Nintendo releasing these things so damn fast lately, I'd have to worry about going home, unpacking it, then reading about the next-gen DS that's about to bury my recent purchase. Y'know, just like an Apple product