Its essentially the same as most MOBA's, aside from the third-person over-shoulder view. And the (mainly) sci-fi orientation vs the generally fantasy based heroes in others. (Though there are several "space-fantasy types, and a couple that seem straight fantasy)
The big alterations are the super-speed mode you start in/go into after 5 seconds of non-combat. Which they've gone back and forth on whether they're removing or altering it.
The "Amber" currency to buy your upgrade cards can be obtained via kills as per traditional MOBA, or setting up and retrieving from Harvesters over time. So there's a bit of an extra element in establishing control of those and maintaining it. PArticularly for your junglers.
The Card system is probably the main thing that you'll hitch on. Rather then being able to buy whatever from the available items over a match, you have to use a deck of cards you choose at the start of the match. You can have up to six cards total. There are "Equipment" cards, which are your base items (also potions and the like), then "upgrade" cards. You can put up to 6 upgrade cards on an item, which generally increase its base stats, and usually unlocks a final bonus after you complete the cards upgrades (at least 3 to do so). Potions and stuff can't carry upgrades though.
Outside of premade basic starting decks (which range from functional at best, to useless for more complex heroes), you get new cards available by levelling up your account/hero/weekly challenges/daily chests/etc. Since the cards are mainly RNG packs though, its possible you may find yourself lacking a key card that would give you an advantage with a specific hero. The cards have different amber costs to deploy in game, and there's not really any ultra-potent cards that negate skill, but there is that tiny bit of potential pay-to-win going on where someone who's shelled out cash to get more card packs then you may have a better set of available tools.
Its also still in beta, and there's obvious balancing issues as a result. Matchmaking seems significantly suspect, and there's no separate ranked mode (or any alternate modes like Arena or smaller then 5v5)