A tie between The Last of Us and the first LittleBigPlanet. The Last of Us is a much better game than Uncharted 2 and is a better produced game than LBP in my opinion, but I'd give the ultimate edge to the first LBP. As good as TLoU, I've played games with similar systems and concepts before. The Last of Us does it better than any of those games, yes, but I've still seen them before.
LittleBigPlanet was something I've never seen or thought could exist before. It sucked up so much of my off-time by myself, friends, and even my parents. Creating levels, playing in someone else's pod, listening to podcasts while creating, playing survival levels online with buddies, DLC costumes and packs, the parodies, music levels, etc. I love that game.
I don't like GTA games that much so the only game coming out for this console generation that may have a chance at topping LBP is Persona 5 if it comes to PS3. Even though it'd be a sequel to my favorite game of all time, I love that series so much that I'd buy whatever system it came out on.
So in closing, I'd give the award so far to LBP as my most important game of this console generation. Best overall game? The Last of Us. Sackboy takes the PS3 and I hope Media Molecule does the same for PS4.