I don't play it anymore, but there probably isn't a way I DIDN'T play it at some point.
I'm rather partial to Destruction, but I've gone back and forth about 70 times on 1 or 2 handed, Shields, Light/Heavy Armor, and Archery.
I have no fun with Conjuration, Alteration is useful but Paralyze isn't as much fun as an Icy Spear, and Illusion is fun but only in small doses.
Restoration is compulsory, and I wish dual casting were actually useful for it. It doesn't affect the Turn Undead spells at all.
Alchemy I use for money making, and Enchanting I use to make magic viable. Smithing I get up to Glass, because even though I really like Dragon Scale (not the helmet though) I loath dragons, so it does me no good because they don't exist in my Skyrim.
More often than not I go with Destruction, One handed/Blocking, Alteration to get 2 perks in Magic Resist (I'm a Breton with Lord Stone and Mara Agent), Enough Restoration to get MP Regen perks and Stamina restore/decent Healing spell, Light Armor, Enchanting/Alchemy, Enough Sneak to get the odd throat cut.
I prefer War Axes overwhelmingly but most of them look off to me, and they get almost no finishing/stealth killcams so I end up using Swords. the character I actually did everything with used Battle Axes, but I hate how the handle extends like 3 feet above your head while stowed and the new "headbutt" kill is SO FUCKING STUPID LOOKING. So I no longer use 2 handed other than greatswords.
I would use daggers, but the double power attacks just ruin it for me. It looks wrong, and feels like cheating lol.
I like archery, but HATE looking for arrows that miss, and using bound bow even more than that. I usually miss due to being able to see an enemy at a range beyond where my arrow can hit a valid target.
i.e. I see a mammoth about 80 yards away, I loose, the arrow passes through the mammoth doing no damage, the mammoth gets aggroed and I find my arrow in the ground right behind where the mammoth was if at all. The ground eats about 1 in 7 arrows. Its especially annoying with deer.
That's why I prefer fireballs for all my free leather procurement.