Most satisfying kill in Fallout 3?

[TUNNEL_SNAKES_RULE]

Sorry if this has already been done.

Nathan...and Lucas Simms.

Blew Nathan's head off,and threw three frag grenades at Lucas,before finally running up to him and waste all of my assault rifle ammo on his smug grin.

 

[Yegargeburble]

Megaton. Went through with a Flamer, laughing maniacally while they screamed and tried to run...good times.

 

[RebelRising]

Killing a slew of Super Mutants by setting off a chain reaction of vehicle explosions along a highway. It was awesome. I couldn't actually loot them afterwards because I couldn't find anything left of them.

 

[Audemas]

I went through Tenpenny Tower with a Flamer and burned all of the people inside and then I let the ghouls in. Also, when I finally found and killed the last Behemoth Super Mutant, I got really tired of looking for that bastard.

 

[[Gavo]]

Megaton.

I've pretty much beat the game, so I got out my MIRV, turned on god mode (PC version).

Then I shot it up into the sky about 10 times, then turned off god mode. My body flew to heaven.

EDIT: Also, I shot a wall of cars a few times, and watched the Raiders fly.

And the time when I shot a grenade in a raider's hand, blowing it up and killing the pair of them.

 

[Piemaster]

Probably when I threw a grenade at a Talon Mercenary and instead of it killing him, he was shot into the air, where he promptly fell to his death.

 

[Caimekaze]

I took down a mirelurk hunter with some mines, and my fists.
I was playing an explosives character. Who'd run out of explosives. All I had were some mines, so I paced two, got his attention, ran back, watched the explosion, ran in and punched him. Dead. Level up!

 

[IxionIndustries]

I killed one of the vault security guards, with a baseball bat in VATS, and I landed a killing blow. He went straight up against the wall.

 

[ekkaman]

.44 pistol 100+ yards open sight on shot kill on murlark first time i used the guy

very close second railway gun crazy time rivit city ever head pinned to wall or roofs rofl lots of screen shots

 

[RebelRising]

Also, shooting a grenade while it was still the Mutant's hand, blowing him to smithereens.

 

[ekkaman]

oh oh vats nad into head point blank for a crit funny funny stuff looked like a exploding fist

 

[scotth266]

Also, shooting a grenade while it was still the Mutant's hand, blowing him to smithereens.

I do that a lot. Free kills!
I have to say that using the Lincoln Repeater to take down entire towns is very satisfying.
Also, look at this vid if you haven't already:

http://www.youtube.com/watch?v=Jowfxw-f_EE&feature=channel_page

Far out, man... REALLY far out...

 

[XXplos1ve]

I Killed a Super Mutant Behemoth with the MIRV,god mode(Lets you fire away without having to reload or use ammo and Has Unlimited Action points and has the normal stuff that comes along with god mode)and good ol' VATS.I basically just kept clicking on the super mutant behemoths body and when i was done clicking...there was a huge bright light...and the super mutant was dead and so was Fawkes and Dogmeat,so i had to reload a save game and do it again
it was more fun the second time

 

[IsoNeko]

The Naked Behemoth, with a Pistol, at Level 4.

 

[Dragonnights]

Shoot a guy with the guess rife from like 200+ft in the face his head plooped of and landed like 20ft away.

 

[Jaedon]

After setting off the Megaton nuke, and hearing Tenpenny comment about wanting to see another explosion like that again I thought.. 'm'kay..' and lobbed a mini nuke at him and Mr.Crowley, knocking them both off the building.

 

[The Shade]

I was just playing a while ago. New character (only lvl 6) and was facing two well-armed Raiders. I just had a 0.33%-repaired Hunting Rifle with a handful of ammo.

It took an agonizing number of shots to take down the first Raider, and he did a fair amount of damage to me before he finally went down. I had, I'd guess, about 4 hp left when I turned to the second Raider, who had full health, and was charging me with his Sawed-Off Shotgun.

The voice in the back of my head said, "So this is it? We're going to die." I realized I hadn't saved in far too long a time.

Lacking any Action Points, I quickly (and roughly) took aim at his head and hoped for the best, pulling the trigger. If I missed, not only would I be left with a single bullet, but the Raider had just finished his reload. It was now or never.

Almost instinctively, my thumb twitched upward at exactly the right time, because as I pushed "fire" it locked in perfectly. The Raider's head exploded with a satisfying one-hit mess.

The Wasteland was silent again, the Lone Wanderer standing there, haggard, over the mangled Raiders. All I had to say was this: "Fuck you."

 

[TUNNEL_SNAKES_RULE]

Priceless...Just priceless...Another of mine was when I killed Megaton's clinic,including the patients and the doctor,and looted the dinghy hell-hole.And when I went outside,no one seemed to care...

 

[blaze96]

I killed everyone in Megaton, Underworld, and The Lincoln Memorial (escaped slaves) with a dart gun. It was fun to just shoot them and watch them fall over, lucky I never saved it so I got to remain the Wasteland's Jesus.