I do multiple playthroughs, and in addition to playstyle (stealth, socialist, big guns expert, ect) I also select a given allignment. At first I normally do "me in the game". as was stated there are alot of grey choices, so I went screw it I'll play as me and if I deem stealing someones vodka as the greater good I will. Which got me to neutral allignment. I then found "impartial Mediator" perk so I then consiously went for neutral. Incidently thats harder then I thought, killing 4 people in megaton was enough to shift me from good to evil