Meiam said:
It's a space 4x, so its pretty different from civ/alpha centauri (think you can only build city in specific spot and most of the map is empty). So MoO is the closest things to it (there's no story or end game threat). Personally I think sword of the star (little planet development, mostly focus of building ship and fighting, all race are very distinct), stellaris (real time, multiple end game crisis, lots of little things to do), sins of a solar empire (if you want something more RTS like) are far more interesting. Distant world universe is extremely rough, easily win the award for worse UI ever and it's also very hard to get information that's really important (most of your money come from stations, but it's impossible to know how much money individual stations makes so you don't know which one lose you money). The new master of orion is also pretty lackluster, with not that much to do.
Sword of the Stars is also the only one where you can play on/in an actual 3D map (discounting Ascendancy since you spend more time in other windows, and Predestination since it isn't out yet), though I always set it to flat personally. I also almost always play the Hivers for their stargates (Starlanes Hoooo!), with occasional bouts of Liir. Can't really get a grip on Humans mode of FTL at all.
Stellaris looks quite good, and plays well initially, but it always end in falling into line with an alliance victory or you against the worldgalaxy..It's also mostly a wargame. Not so much other X's. Last time I played anyway.
One will have to wait out the endless updates and free/paid DLC's they are pumping out too..
Sins of a Solar Empire isn't..really..4X..in my book. Feels much more like real-time grand strategy..Grand RTS?
This one is much disputed though, so tastes may vary.
Distant Worlds Universe is only slightly rough..and the information is often quite readily available online.
It doesn't detract from it's prime example as a solid entry in the 4X genre.
You want to see a really rough 4X UI? Try playing Polaris Sector Lumens.
Endless Space is Real Pretty, but shallow and mostly plays out the same.
StarDrive 1&2 and Horizon are bland overall.
Couldn't get Star Ruler 1&2 to work, so I can't judge them. Though I've heard good things.