Thinking about it, if the first movie was about fear, and the 2nd about rage and chaos, the 3rd should be the fall and rise of Gotham, but to rise, it has to fall deep. I still think the Penguin is the perfect villain for this movie, a small, fat entrepreneur who waddles into Gotham, rising from the seedy underbelly's shadows to high power, controlling the entire city and plunging it into his own play tool.
However, having Catwoman evolve could be nice, a thief who doesn't try to fight Batman, but woo him to slip up, to fall in his duties more, to be linked as an accomplice to this woman who is robbing the city so hard they don't know what hit them.
Also, Bane is an interesting choice, because reading a bit on his history, having him have brains AND brawn creates the "perfect monster", a beast who uses rage, but controls the rage. Plus, according to the comics, Bane not only "breaks the bat" physically, but being able to find out just WHO Batman is? That's what you call lethal, a villain who can physically harm Batman, and also mentally defeat him. If you want to fall low, and need a place to rise from, why not from under the boot of a man who can beat Batman in more ways than one, and if it plays off of the ending of The Dark Knight (which I'm sure it will) and gives us Batman as the enemy, than not only can Bane defeat Batman, but is heralded for it. If Batman is seen in the eye of the people as the enemy, than Bane, the true villain, can be seen as the Hero, and thus, the fall of Batman, and having to rise to the hero of the land, to the city's protector, The Dark Knight Rises to savior of Gotham
This should prove interesting, as for the actors, it's hard to say, but so far we've got a hell of a Joker from Ledger, hopefully the person who gave him that role chose Anne and Tom for these roles, if so than we've got a good shot at a great movie