I appear to be one of the few people who is looking forward to both InFamous 2 and Prototype 2 (I really don't undertand why a lot of fans of each game feel the need to spew so much hatred and bile at the other one, but I guess that's fanboyism for you). I always considered InFamous to be the better game on the technical side (just in terms of how the game is put together), but Prototype was a lot more fun to just play.
I know the first prototype gets a lot of hate due to the lacklustre world, pointless side missions and confusing storytelling, but the developers have admitted these are area that needed imroving, so it's a really good sign for the sequel.
Besides, how can you not be interested in a game that lets you fire yourself through the tail of a helicopter, rip a missile launcher from the top of a tank or just rip the arms of a giant monster?