It depends on the genre. Calling Rome: Total War my gold standard for all of gaming tends to feel a bit apples-to-oranges when contrasted against, say...Fallout 3 (my favorite RPG), Tropico (favorite city-builder), or even Alpha Centauri or Rise of Nations (favorite straightforward turn-based and real-time strategy games, respectively---even though Total War combines both sub-genres into a genre that is truly all its own.)
The five games mentioned above are (though not in order) my five favorite games of all-time and I wouldn't compare one to any of the other four because the comparison wouldn't be inherently valid. But to compare, say, Rome to Medieval 2 and Empire and Napoleon, or Fallout 3 to New Vegas and The Witcher and Morrowind and Mass Effect, or Rise of Nations to Age of Empires or Starcraft...you get the idea.
Hell, even Tropico as "city builder" is a comparison that breaks down if the game's compared to SimCity 4 as opposed to, say, Children of the Nile or Caesar 4 (which are much more like Tropico than is SC4.)