Which in-game decisions/actions have made you feel guilty?

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Sir Seagull

Knight of the Picnic Table
Jan 12, 2011
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Usually when I finish a sandbox game I usually keep playing after the credits, pretty much to look for collectibles and whatnot.
Though after I finished Infamous 2 (Evil) I just couldn't keep going and turned off the TV without a word.
So have any games made you feel really, really guilty?