Trolling as a joke. Not trolling as in actually trolling, because that can actually be funny; but when you get in an actual argument about real things (in real life), and the person losing says "u mad bro?", it just feels like the ultimate cop-out in debate. There's just so much overuse in that meme.
As for memes in general, I'm just tired of them. I got into them about a year or two ago, and then I stopped about 6 months ago. They just weren't doing anything humorous or new for me. Unfortunately, as soon as I abandoned memes, everybody else in my school found them through iFunny and Damn!LOL and immediately felt better about themselves for being "hooked" on "internet culture". This isn't bad in itself much, but the fact of the matter is that if you expose something to the masses, its going to get broader and dumber.
And so was the case when all of these memes that were made a year ago got reposted on Facebook and Pinterest and people started using memes in the wrong context, and misquoting them in real life. Meme pages for universities and other areas (such as cities, states) began popping up on Facebook producing the lowest common denominator in comedy.
For example, let's say that there is a page called "Texas memes". An example of a meme here would be a map of Texas, with a trollface copy pasted onto it (most likely in MS Paint), reading "lol u hot bro". That would be the joke, because Texas is pretty hot.
I should end my rant here, because this is starting to get pathetic.
BOTTOM LINE: Memes should really just all die. 4chan is ahead of us here, the only meme that they have left is the "you rustled my jimmies", which still has some humor in it (for some reason). Memes are so misused and unfunny now that they need to just die while there's still some nostalgia about them (making them the internet's equivalent of Sonic games).