For a show targeted at little girls, I remeber it having a lot of action, every episode of it ends with the Power Puff Girls beating up the villian of the week. I'm pretty sure you could reskin it as any number of kids action shows and it would be very similar.
Strangly I've never heard girls talk about this show, while a lot of male friends have seen and enjoyed it. It's not like it was a girly show, besides the main characters. Anyway, I remember watching and enjoying it as a kid and not being ashamed.
A show I'm slighly emmbarrsed about watching though now is cougar town, even though it isn't a kids show, it started out billed as a show targeted towards females even though now it's an ensemble comedy, even still I'll talk about it if it comes up, but i won't make any effort to bring it up.