From what I've seen out of videos of The Last of Us, there are quite a lot of gruesome ways to die.
The bits at the beginning where you can have Joel get mauled by an infected while he's carrying his daughter made me cringe quite a bit. Also, the way the game cuts out the bit where Joel either gets bitten or gets his face ripped off by a bloater is kinda eerie as well. You kinda know what happened, but at the same time, it lets you use your imagination to picture the result. And the imagination can make some pretty scary things.
As for personal experience, while I was playing MGS2, I had to walk across this pipe or girder and I accidentally slipped on some seagull shit and fell into the ocean. Kind of an embarrassing way to die. :/