Probably not, unless its key to the person's character that they arent. I dont judge on Race, Gender, Creed, or Sexual Preference cause I'm not shallow like that. Oka that was being a little mean, but just saying is all.
Still, I'd like to direct us toward the Episode of Extra Credits when they covered Sexual Diversity.
Why yes I do mean that one, thank you me. That was intergul to the character and plot (kinda?) and when I found out Naoto Shirogane was a chick that wanted to be a guy, that honestly surprised me and made the game better (not that it really had to try to, Persona 4 was amazing). Mostly cause I had never seen a game dare to touch on both issues at once or hell, even one with any real conviction, and partly cause I thought I could fall in love with the character. But I dont swing that way (noting against the homosexual lifestyle. I've thought about it and honestly almost tried it but in the end it wasnt for me [and weirdly enough I broke a kid's heart even though I told him I wasnt homosexual and he knew I wasnt, yet he still decided he would wait for me or get a sex change for me... but thats neither here nor there]) so I didnt get that kinda emotional attachment that I had with Yukiko, who I fell for.