Hmm I can't remember if all of these were presented at E3, but they're ten of the games I'm most interested in right now. The lower half I'm unlikely to get, but I'll be checking the reviews for all ten.
1. Prototype
2. Halo 3: ODST
3. Mass Effect 2
4. Crackdown 2
5. Assassin's Creed 2
6. Modern Warfare 2
7. Halo: Reach
8. Left 4 Dead 2
9. Scribblenauts
10. Alan Wake
There are also some intriguing PS3 games, starting with Uncharted and Agent, but sadly I don't own the console.