Here's what Dead Space taught me:
If a ship full of 1,000 people is not answering, signaling, or showing any signs of life whatsoever, turn around and come back with back up. If, out of all those people, no one has been able to notify or response to rescue in any way, a small detach of five people is not going to be enough.
Whenever someone on your team starts to lose it, kill them. Insane laughing or worshiping the very things that just slaughtered everyone qualifies. As soon as the words, "That's it. We're all going to die. They're going to kill us all!" leaves a person's mouth, shoot them. Bad for moral, and those that have seen Dead Space Downfall know what I'm talking about.