Well, she seems pretty tensed up, giving her a sort of artificial look. Something about the image quality makes it look like she is covered in floss(dow?). And is that a lazy eye, or is my mind playing tricks on me?
The background color gives the picture a slightly darker look; sort of looks like you're walking around in a horror game and just found this girl, illuminating her with your mandatory horror game flashlight. Her dilated pupils would indicate a dark surrounding, caffeine consumption, or an interest in the person looking at the picture; perhaps subconsciously communicated. That or fear. In addition the door hinges in the background makes the photo look unprofessional.
I thought the picture looked a bit creepy upon the first glance, but as I kept looking I just felt neutral.
Come to think of it, she looks like someone you have encountered in a dungeon in Oblivion while using a light spell. Maybe I should have said "Unreal" look instead of "artificial"? Eh? Anyonone?