How about we do over with the whole 'ruined US cityscape' idea and try something new. Maybe, an RPG with FPS elements set in post-apocalyptic London Can you imagen fighting your way through Parliament house with hordes of mutant politicians trying to claw your nipples off and take all your money.
I would much prefer a game set in England, why does that never happen? The closest thing we've come to an english game so far has been either GTA London 1960s or Fable, and even Fable tries to hide the fact that it's set in england by calling it 'Albion'.
England was originally named Albion, then it was named Anglo-land, then England. So it's not even a particularly clever disguise. But why disguise it at all? Are Americans completely incapable of accepting that there are other countries in the world? It's been assumed that if you don't set your game in America, then you won't appeal to the American market, but why? Americans aren't bad people who are self-centred and xeno-phobic (well most aren't anyway). So why not mix things up a bit.
Also, I'm not counting 'Resident Evil' because they're clearly making a statement about how terrible all these other countries are compared to America, and that an American should go in there and feed them some liberty, democracy and bullets.