Best Comic Hero / VG Hero Team up you can think of

[L4hlborg]

Micky the Mouse and Marcus Pheonix.

Imagine: Micky annoying the crap out of everyone with his voice and then Marcus chainsaws them, relieving his enemies from their raped minds.

 

[superspartan004]

since I am an FF fanboy I'd have to go with

Cloud
Squall
Vincent
Zidane

 

[Wilfy]

Kratos and .... I'm not sure, Kratos would kill anyone on his team.
Meh, I'll put him with my LBP character, because not even Kratos could kill a zebra with a saucepan.

 

[Prowers]

Ben from full-throttle.

 

[Hikikomori Ookami]

Master Chief and Marcus Phoenix

 

[Salem_Wolf]

Alex Mercer and Wolverine. Need I go on?

 

[Erana]

Spoiler: These guys

and the infected from L4D.

 

[DGenius]

I gotta go with Wolverine and vega...they'll tear everyone to shred (pun intended)

 

[USSR]

All you need is this man on your team:

Spoiler

o.o
*jaw drops in amazement*

 

[molester jester]

Dante and Deadpool - just for the banter

Edit infact Deadpool with anyone, the world needs more Deadpool

 

[John Smyth]

Dante and Deadpool - just for the banter

Edit infact Deadpool with anyone, the world needs more Deadpool

with peach, with peach

 

[Marv21]

Jackie Estacado / Albert Wesker.....almost too much badass for 1 team!

 

[NeedAUserName]

Solid Snake (or Big Boss, Naked Snake etc) and Snake Pliskin.

 

[Pm0n3y]

Deadpool & Rorschach. if you seen Marvel/DC on youtube then you'll know what im talkin about

or even better Alex Mercer and (evil) Cole McGrath. they'll put their differences aside for the sole purpose of causing chaos

 

[sms_117b]

How about Sonic (from the Mega-Drive days) and The Flash, crime and evil doings would just stop for seemingly no reason!

Maybe Iron Man and Squall that could be a interesting dynamic

 

[KarumaK]

Wolverine and Kratos.

And the rivers will run red...