The original electric car?
Call of Duty: Spanish Civil War. Or Russian Civil War. Or if they can't be divorced from American patriotism, Korean War.
Open-world Deus Ex.
A sequel to Planescape using the Elder Scrolls engine. Why not, it happened for Fallout!
Scrap all plans for the Dead Space trilogy, and divert the funds to this- System Fucking Shock 3. Not only did they not acknowledge that it's a remake, they left out the best character so it wouldn't be an obvious ripoff.
Dune RPG.
GTA mixed with I Am Legend, the original book, not the sub-par movie. Why have I never driven through a sidewalk full of zombies in a '76 Impala?
Ender's Game RTS. It's in the damn title.
Starcraft...um, well, just about anything besides adventure game. It could even be a movie, but only if Paul Verhoeven directs. Speaking of that...
Starship Troopers RTS.
Half-Life RTS. Ha. Ha-Ha, Ha. This would blow.
Movie-wise, A Canticle for Leibowitz would have made a better movie than Book of Eli, because it deals with the same things in a grander fashion, and presents Christianity as something other than a simplistic believe-or-die plot convenience.
Shits n Giggles- Batman discovers Bioshock pre-collapse, finds he has much in common with Andrew Ryan...