I usually find myself using the following:
Anti-Materiel Rife (GRA): As many others have said, it just does ridiculous damage, not to mention the fact that it has a silencer equipped.
Christine's COS Silencer Rifle: For when I need long range damage done but don't want to use the rarer .50 ammunition.
Katana: For when I feel like melee.
Hunting Shotgun: Love the feel of this weapon, prefer it over the riot shotgun for a reason I can't seem to remember...
9 mm pistol: For bloatflies, radscorpions, etc. or for when I feel like a real challenge.
A Light Shining in Darkness: Ridiculously powerful handgun, use it as my primary weapon.
.45 Auto Pistol: Only use it for the silencer. Not as good as ALSID, but still decently powerful.
I wear Joshua Graham's Armor, the 1st Recon Beret, and sunglasses with it.
Anti-Materiel Rife (GRA): As many others have said, it just does ridiculous damage, not to mention the fact that it has a silencer equipped.
Christine's COS Silencer Rifle: For when I need long range damage done but don't want to use the rarer .50 ammunition.
Katana: For when I feel like melee.
Hunting Shotgun: Love the feel of this weapon, prefer it over the riot shotgun for a reason I can't seem to remember...
9 mm pistol: For bloatflies, radscorpions, etc. or for when I feel like a real challenge.
A Light Shining in Darkness: Ridiculously powerful handgun, use it as my primary weapon.
.45 Auto Pistol: Only use it for the silencer. Not as good as ALSID, but still decently powerful.
I wear Joshua Graham's Armor, the 1st Recon Beret, and sunglasses with it.