It's pretty horrible and for me personally, it's a major turnoff.
I bought the first Bioshock not really knowing what I got myself into. It just looked and sounded like something pretty new, and interesting enough to want and grope at and play around with. I found it to be one of the best experiences since, say, Halflife 2. Shooty-shooty stuff, a story worth mentioning, some twists, some unexpected moments, a bunch of so-so ending, but the ride was very well worth the price of admission. The box cover you ask? If I remember correctly, 'twas just some rendering of a Big Daddy of sorts? Mysterious enough for the uninitiated, a welcome memory-inducing trigger for the battle-hardened, spliced-up players. Because this first one was such a darn pleasing ride, I pre-ordered the second one in the nifty butterfly box edition. Super ultra nice sweet box, but the game was rather... OK, with a sprinkle of 'meh' added. It felt more like BioShock 1.5, or a mod of sorts. Female, swift, death-from-above enemies to contrast the lumbering, charging, very earthbound Big Daddies? OK. Replace the male mortal enemy with a female one, with a thick accent? Uhm... not quite that original, is it.
Now with BioShock 3, everything pretty much pissed me off already. I never asked for timed-release info on all enemy types. That was total bollocks. Now, before even got released, I'm pretty much bored and annoyed beyond saturation, and the cover reminds me not of my adventures unda da sea, since it looks just like anything out of the Uncharted series, or any other random action-y game with pew pew shooty guns and stuff. It's also the first Bioshock where I am allowed (i.e. forced) to have a look at my player character hero type of sorts, even before we got properly introduced. It's lazy, it's wrong and I'll hold back to see if all that fancy new stuff isn't, in fact, some of that frothy Molyneux foam that will actually pretty much kill the franchise dead, dead, dead.