Well, here's my arbitrary "long time lurker, first time poster" line.
Now, the answer here is clearly Hyperion by Dan Simmons. There's been some rumors that it may become a tv show akin to Game of Thrones, and that Bradley Cooper could be involved. The first two novels, or better known as the Hyperion Cantos (Hyperion, followed by the Fall of Hyperion) would probably have to be stretched out over three movies. If they made two, I imagine they could weave a lot of the Pilgrim's stories over the plot effects of The Fall of Hyperion, but you would lose some context. And if it was successful, they have a beautiful sequel/successor series that holds the potential to be one of the most visually inspiring works of film and media, ever, (Endymion, and subsequently, The Rise of Endymion).
I also wonder if anyone around here has read this series, or at least the first two. And if so, why have I not seen any posts about how Mass Effect 3's ending was a carbon copy ripoff of the The Fall of Hyperion? It's so obvious! In fact, the Reapers as a whole function almost exactly like the malicious sect of the TechnoCore. Blowing up all the Mass Relays is exactly what they did in Hyperion with the Farcasters. Mass Effect 3's ending was a lot of things, but one thing I haven't seen written is that it's a near direct ripoff of Hyperion, and that lack of originality is the most grievous offense of Mass Effect.
TL;DR
Hyperion series, bitches. And then Endymion.