Oh yeah.
At the moment in university I'm doing Creative Writing, and one of my groups has a criminally small reference pool of materials, so whenever I reference anything from comic books, videogames, the entire sci-fi or fantasy genre, I'm going to get blank stares.
There are people who honestly think playing a few rounds of CoD and no other game (except maybe the Madden Sports games) makes them hardcore gamers.
Thankfully, my sci-fi literature class is a lot more nerdy, so whenever anyone makes a nerdy reference, everyone gets it, including the tutor.