Its an unrealistic video game, I can accept some crazy art direction in details. However, it is kinda a plus, in a way. She fights a lot, she keeps in perfect physical shape and has a lot of power, of course parts of her are more beefy then then is strictly ladylike. Congrats to Capcom for going in a direction that sacrificed some (Obviously not ALL) perfect woman stereotype for a I-Can-Crush-You-With-One-Hand look. Theres plenty of reasons why she would have well developed thumbs.(Though it is a strange thing to accentuate, I think the picture framing is partially to blame.)
Also, I really can't complain about her having huge legs. Anyone who does, I would like you to lift your leg off the ground, and kick in front of you. Instead of putting it down, do it again. And again. And again. I think you know the move im talking about here. How fast are you doing it, and how quickly does your leg tire out. Now think of Chun Li. Still blame her for having huge legs? I didn't think so.
Of course, ive always liked Chun Li for being pretty cute but also kinda scary are brutal, so maybe im biased.