WhiteFangofWar said:The SA-X from Metroid Fusion is one he didn't catch that I found panic-inducing during the first playthrough. There's a nice closeup of its blank, white, pitiless, inhuman killing machine eyes when it first arrives, and it's armed with the unstoppable arsenal from Super Metroid that I mastered long ago. Knowing that you are being hunted by a version of you that is several times more powerful is quite stressful when you can't find the way out, at least until you find the flaws in its AI...

That thing gave me nightmares for over a year after I first saw it. In fact, they didn't stop until I picked the game back up again after having spent most of that period away from it (to be fair, I abandoned the game because I got stuck at one part, not because I was too scared to go on) and got to the part where the SA-X got eaten by a swarm of baby Metroids. No amount of therapy could have done more for me than that moment; I wasn't even particularly bothered by the subsequent revelation that there were ten more of them running around the station.
An honorable mention goes to the V-rexes from the King Kong game, whom you can't kill when you're playing as Jack (i.e. most of the time) and instead must distract, run from, and delay as much as possible. The juvenile V-rex you have to fight as a mini-boss at around the game's midpoint or so isn't exactly easy on the pulse either.