I use to find it very uncomfortable playing as a female character, but that was mainly due to my own problems and issues with my masculinity. Now that I've grown up a little and am not longer fixated on appeal to some dopey male stereotype, I happily play as female characters. Seriously, I've got absolutely no issue with it now a days, just so long as the characters are good I'm happy as a clam. This isn't based on anything, but I suppose it could be justified that my former position is where a lot of people are at currently in the gaming world, stuck between childhood and manhood, unsure of who they are and where they're going and most importantly, unsure of their masculinity. Just as there are these archetypes that woman are expected to base themselves on (Not particularly in gaming, more in a western society type manner), so too are men and I think there's still a lot of growing up to do. Just look at the way that men are idealised in gaming, you can't tell me that there aren't hundreds of men out there unsure about their masculinity based on that. This is going to be a problem for as long as our medium is stuck in this state and it's going to take some revolutionary developers to really move the medium into maturity.