It really is case by case. Some disagreements, well, most, nearly all aren't worth it. Generally, they stay neutral with me, strangers that disagree.
I'd rather have something more solid to hate someone for. More what they present than them disagreeing. If someone's nothing but butt to me, I'll see'em as an ass.
Of course if the disagreeing person is hateful, spiteful, belligerent, oppressive, intolerant, or some such, I can certainly feel disgust, loathing, no desire to talk with them further, dissapointment, annoyance, and such negative, but temporary feelings.
Lets not forget willfully ignorant, blind, and/or stupid to foster such genative perspectives of a person.
People who are intolerant, bigoted, and such, I try to tolerate them, but they certainly can't ask me to. Rspecially if they're sexist, or racist, or anto LGBT. PoVs like those will dredge up negativity, obviously. I certainly won't like these people.
This makes gender issues in games something of a sticky situation sometimes. Even with the often reasonable people of the Escapist.