As a relatively new newwhovian all I can really say is that starting from the reboot works just fine. Every now and then you won't quite follow but just bear in mind that's mostly intentional.
What you should pay attention to however, is that there have been a bunch of 60 minute specials that you can't skip without missing vital events. But depending on how or where you get the episodes, these specials could be available somewhere seperate from the normal episodes or simply won't be available at all. So I recommend keeping an eye on the episode list here: http://en.wikipedia.org/wiki/List_of_Doctor_Who_serials so you don't accidentally skip episodes.
What you should pay attention to however, is that there have been a bunch of 60 minute specials that you can't skip without missing vital events. But depending on how or where you get the episodes, these specials could be available somewhere seperate from the normal episodes or simply won't be available at all. So I recommend keeping an eye on the episode list here: http://en.wikipedia.org/wiki/List_of_Doctor_Who_serials so you don't accidentally skip episodes.