The moment I see DS I read it as 'dual screen', so yeah you're right it's not a good one.Dan Steele said:DS
could mean
Dark Souls
Demon Souls
Dead Space
Demon Scrolls
Though incredibly annoying to spell out out loud or in your head, normally the longer the acronym the better, as it's harder to confuse with another more easier to search a meaning for. I found that whilst recently watching TWGOK (short for the World Only God Knows). Shorter ones that are more obvious are fine, for example I can't think of any other meaning behind HL2.
The way I was always taught at school was to put the acronym meaning in brackets the first time you use it (or vice versa), then you can use it as many times as you like. Simple.