Short answer: Most of them.
Short-ish answer: Yes, that includes Jazz Jackrabbit, Keen, Terra Nova: Strike Force Centauri, Descent I, Descent II, Doom I, Doom II, Duke Nukem 3D, Fallout 1, Command and Conquer, Warcraft II, Jetpack, Civilization, One Must Fall, The Elder Scrolls: Daggerfall (and Arena, to a lesser extent), Master of Magic (still with no true sequel, though I know there are plenty of spiritual successors), Alien Carnage, Alone in the Dark, Worms, Xargon, Xatax, Zone 66, Secret Agent Man, Crystal Caves, Cosmo's Cosmic Adventure, MDK, Major Stryker, Stargunner, Terminal Velocity (actually pretty much any Apogee/Interplay/Looking Glass Studios / etc. game), Lemmings, Prince of Persia, almost any lucasarts adventure game, many more I can't be bothered to list.
Star Control II, obviously, but most of the things i'd mention have been said already.
Wary Wolf said:
Imperioratorex Caprae said:
Wary Wolf said:
Hmm...
ZZT
But then, the DOS age had a game called Little Big Planet anyway, but whatever...
I believe you mean
Little Big Adventure aka
Relentless: Twinsen's Adventure. Great game and a wonderful sequel.
Gah, you're right. Sorry about that. Case of 3:30itis. A cruel disease designed by soup and coffee corporations.
Theme Park
Was another in the similar vein to Theme Hospital, but was be a very intricate and deep simulator. Unfortunately went over my head when I was a kid, but had a nice difficulty setting that catered to young minds. Still, going bankrupt and then the subsequent suicide always disturbed me...
Slipstream 5000
Yeah, there were plenty of racing games. But who wants cars when you have jet powered aircraft that are armed to the teeth? Fun stuff. AI was dumb, but those days, they usually all were.
Skyroads
Another freeware program, that is a curiously fast paced and unforgiving puzzler. Prepare to explode over and over and over and over again. But get that feeling of satisfaction when you FINALLY beat the level.
I actually beat ZZT for the first time in 2008, even hooked up an old PC with big floppy disk to install it.
Skyroads is amazing. I'm surprised it's freeware. I hope you played the Christmas version too, some REALLY hard maps in that one.
Slipstream 5000 is actually retro game of the week over at milkstone studios. Not gonna post the twitter link, but yeah. I loved SS5K.
The Madman said:
Sam & Max: Hit the Road is still one of the best damned adventure games out there. With a great sense of humour, fun visuals, full voice acting and a great soundtrack, and even well designed
(If crazed) puzzles it stood out even in what was then the crowded point & click adventure genre and continue to stand out as one of the quirkiest and funniest games I've ever played.
Goddamn I love Sam & Max, I wish Telltale would ditch all the episodic story stuff and make another Sam & Max game already.
S&M:HtR is probably the best game I played when I was 10 or 11. I remember my dad and I had to go to some game store 30+ minutes away to check a strategy guide for one of the ridiculously impossible puzzles, I believe involving the ball of twine. Great game, for sure. Tons of silly memories. Very easy to mess up even at the beginning, not grabbing the cash from the mouse hole in the office ^^;