I was pleasently surprised by Bulletstorm.
It might not have a particulary clever design, but it seems to be a very fun over-the-top-don't-take-us-seriously affair that positively reminds me of Shiny's The Wild 9.
Also, i wasn't really looking forward to Portal 2 because i feared the novelty has already worn of, but what has been shown at E3 was funny and, above all, the puzzles shown had some crazy cool solutions.
And, while i'm still filled with doubts, i do hope that Deus Ex 3 is as awesome as they claim to be.
And last but not least: Finally a REAL GOOD OLD Need For Speed with Criterion's NFS: Hot Pursuit. No experiments, no kiddie "Fast & Furious" stylings, true NFS gaming with overpriced sports cars, vast, scenic tracks and lots of police!
Other games i look forward to thanks to the E3: Kirby's Epic Yarn, Rayman Origins and Call of Duty, Black Ops