Hmmm, a couple of things i suppose.
1) Bio-engineer zombies and vampires. The Zombie would be made by attempting to animate a dead body, so it moves about and responds to stimuli but without a mind. Vampires would be made by gene splicing humans so to give them Vampire traits. Teeth, craving/need for blood, perhaps super-human strength, aversion to natural light, but no they won't sparkle.
I might then have a zombie V Vampire fight, just the lulz.
I would also try to create new species via genetic modifcations, and modify existing ones. I might try and make a flying pig. If i carn't make a flying pig via biological means, i will hook up its brain to mechanical wings. It can be a cyborg pig!
Ooooh! I would make the Borg!!
1)Make cyborgs
2)Give them the will and ability to convert biological beings into cyborgs
3)Hive Mind
????
Profit?
Then i will have a Zombie V Vampire V Borg fight, and i will watch from my blast-proof fortifed observation deck.
Finally, experiment with mind control and other mental-stuff. Perhaps i could try to increase the powers of the human brain to such an extent that i can make a brain with "psychic" powers, so it can read other peoples minds and poseses telakenetic powers, i might apply some of these features, if proven safe, to my own brain. I would also, through drugs or cybernetic technology, develop methods of mind control.