Want the list?
1. Collect all 8 Balls, and I mean ALL
2. Acquire Lucky Shades ASAP, need to travel wasteland in style
3. The ***** dies, no not Moira, but Gradma Fucking Sparkle. This has been tradition ever since my first playthrough where I was so desperate to get a hunting rifle, I caved an old woman's skull in with a rusty piece of lead pipe. Now I just do it to remember the good old days, where the wasteland was so big and intimidating, I could justify killing an old woman in cold blood.
4. Dogmeat
5. Charon, force to wear either wig, cowboy hat, or Chinese hat
6. Always, ALWAYS, do Reily's Rangers
7. Behead Raiders after battles, create pile of corpses, then pile their heads together elsewhere. Major message to people who pick up this lifestyle, especially fun at larger settlements. Once spent 15 minutes brining bodies to one spot, where I could hang their necks over an edge, and use it as a makeshift guillotine with a Chinese Officer's Sword I picked up off of them.
8. Make home nice and tranquil, pick Pre-War theme
9. Steal Lucas Simms hat, I told you I wanted your damn hat
10. Always talk to Billy Creel, why? Because in my world, he's Billy Motherfucking Creel, the biggest bad ass the wasteland has ever known (next to me), who's raising a little girl
11. Assassinate Moriarty, when he's sleeping
These are just the few things I usually do on every play though that I can think of at the moment.