I got a few, but theyre not glitches.
One was on... damnit I forgot the name of the place. The town on the north full of Deathclaws. On one of the expansions you're suppose to go in the sewers to do... something I cant remember as well. Anyway in there you see 2 ghouls running away from the place. Later you see a bunch of dead ghouls, friendly ghouls actually.
It seemed they wanted to expand their reach and decided to make other towns for ghouls like Underworld. THey decided to place a new town... beneath the Deathclaw infested town... the logic was no one would set foot in that town so they were protected... and stupid I guess.
That was one WTF moment for me.
Another one was on a factory to the south... south west I believe. A bunch of ghouls held up in there. When you get down to the basement you got to kill CHINESE GHOULS. If that couldnt make me go WTF well they were all adoring and worshiping an obelisk or something down there. Dont ask why the hell they worshiped it, or even less why they're chinese, I guess it was an invasion plan but they got stuck... but why the worshiping of an obelisk?
WTF?!
There were others, like the time I took an armor called Sexy Underwear (I placed it on, it wasnt that sexy though, although I felt pretty, Hahaha... I need a woman) and suddenly a bandit comes up to me saying he wants the sexy underwear else he will kill me. Of course I blasted his head off with a shotgun because there could only be one sexy man in the wasteland, but that pretty much made me go WTF.