I'm going to go against the grain and say that a Fallout adaptation would work, but not in a film. Rather, I say a tv miniseries would be better suited for it. Granted, the show would have a tough time trying to stand out, but if someone could get good writers to hammer a good story that feels like Fallout, then that would be start. You just need folks that get the game and its mythos. Look at Hitman. Skip Woods, the writer, didn't seem all that familiar with the game, hence the story took so many deviations from what was already a solid background story. Xavier Gens, the director, claimed to be more familiar with the games, and it showed. At least, that's how I felt about that film. However, my original point still stands. Get people that at least understand Fallout (and make it into a miniseries event, which would probably only happen somewhere like HBO or Showtime), and you may have a chance.