I enjoy many RPG's, card games and board games. Trivial Pursuit, and other "party" board games especially - it's amazing how a game can excite and amuse a room full of people.
"Word Dissociation" - a circle of players, each says a word in turn. The only catch is that the next word must have no possible connection to the previous word, and it's played best with a short time limit. Say, 5 seconds. That was our high school drinking game of choice.
Pente, and Abalone are personal favourites.
I rarely finish a game of Scrabble (offline), but I've played WildWords once at a friends house, and really enjoyed it. http://www.wildwords.us/ If you're looking for something new, it's not a well known game - and nope, I'm not in any way associated with the game maker.