I have a few:
"Chesire, look."
(staring at Bayonetta's tits)"Oh, I'm lookin"
(doing a double take and spotting the missiles headed for them)"Oh, fuck me!"
Bayonetta is full of great ones.
"I think you had so much on your mind that you couldn't even take your next step. You're pathetic, can't even get one thing right without me, can you? Well, if you don't understand it, try just accepting it. Accept that you are weak, accept the path you've chosen, accept that nothing makes sense in this whole damned world! Once you accept everything, you can choose your next path, the one path you really wanna take." - Jecht, Dissidia: Final Fantasy.
"Weakness is the greatest sin." -Golbez, Dissidia: Final Fantasy
"Don't worry, be happy!" - Tidus, Final Fantasy 10
"It's not enough... have got to destroy more! Destruction isn't supposed to make sense! It's only fun when it's senseless! Why create when it will only be destroyed? Why cling to life, knowing that you have to die? None of it will have meant anything once you do! Meaning schmeaning! The whole world's going bye-bye! You included! Life... dreams... hope... where do they come from? And where do they go? None of that junk is enough to fulfill your hearts! Destruction! Destruction is what makes life worth living! Destroy! Destroy! Destroy! LET'S DESTROY EVERYTHING!" - Kefka, Dissidia: Final Fantasy