Real Life by Greg Dean is really the only comic I keep up with anymore, I've been following it for around 10 years now. Great stuff.
Real Life by Greg Dean
Edit: Guess I should follow suit and detail the comic a bit. It's basely loosely, VERY loosely in a lot of cases, around Greg's real life. He goes on adventures with his friends, complains about work, talks about video games, and also tells a bit about his real life. It might sound boring, and at some points, it can be, but I love it.
I used to read CTRLALTDEL too, but just stopped reading, dunno why. I'll get back to it, though.