Obstructive DRM - I can understand not wanting to have your product stolen. But you don't sell a car to someone and not give them the key. DRM should be easy to deal with (legitimately), and not hamper a paying customers enjoyment. Or better yet, just get rid of it. One of the main reasons people pirate games is so that they don't have to jump through as many hoops to play their game.
Forced In Multiplayer - As much as I enjoy playing online with people, I don't think every game needs it. Seriously, if multiplayer isn't in the games design doc from conception, don't take resources away from the singleplayer.
BAD QTEs - The only games I really see QTEs working are games where you're already mashing the buttons frantically. God of War and Devil May Cry are some games that I can see them working in. Also, they aren't needed when there is a lull in the action. Simply pressing B or Triangle once should open a door, unless I'm tearing it down Hulk Style.
Realism - Okay, okay it's good in some games (horror games can make amazing use of it), but most people use video games as a form of escapism. To get away from the real world. I'm not saying games should just throw physics out the window and make really absurd decisions because "Fuck you, it's a game", but not every shooter has to have you die in two bullets, only able to carry two guns, etc. The game should feel as if it's conforming to the rules of it's setting, not our world.
LONG LOADING SCREENS - I forgot what game I was playing recently, but I played it for about 4 hours straight without a SINGLE LOADING SCREEN, apart from when I started up the game. I would die, reload the checkpoint and 2 seconds later I was back able to playing. However, Max Payne 3... I had to watch a 5 minute cutscene, because the game was still loading. I died about 10 seconds into that level... guess what? I had to watch the cutscene AGAIN, because the game had to reload all the resources. While were at it...
UNSKIPPABLE CUTSCENES - Fuck 'em. If they are "locked" the first time through (say once you watch one the game auto-saves and "unlocks" it, and you can skip them any time after that). Fine, but if I have to watch several minutes of exposition because I can't skip it on my second+ time through the game, I'm going to get frustrated. I don't replay games for the story(most times), So I would like to skip them.