While playing Fallout 3 I encountered the random event with a couple raiders beating another one with bats. As they saw me approach they all reached for their weapons, some kept their bats, other pulled guns and one a grenade. I use VATS with my hunting rifle and line up a couple shots, on instant kills/decapitates one guy, another hits the grenade still in the raiders hand blowing him up and the guy next to him. I exit VATS and take cover behind a rock, then when my action points recover is pop out and kill the the one of the two guys left, then finally chase after the last one, who ran away, and deal with him in real time. No damage taken. And if you read all this I love you, very much.