Hmm Freelancer 2, i like the sound of that!
Homm3-2, BG3 & new Planescape adventures are more then welcome aswell!
It would also be nice to see some original 2D click&play adventures again aswell, like true sequels to Sam&Max, Monkey Island, Broken Sword, Full Throttle, Legend of Kyrandia, The Dig, Indiana Jones, Day of the Tentacle, Loom and whatnot. Even tho most titles got their sequels, they're friggin 3D! != true click&play adventures! (Grim Fandango is the only exception, Monkey Island 4 was still crap).
(And i must say, Machinarium was a great attempt as one of the new old games! Altho technically not a sequel and thus off-topic)