I'm 99% in Okami. The last Stray Bead is stubborn as hell. The calligraphy one, for the record.
95% or so on Devil May Cry 3. Did everything there is to do story-wise, but haven't beaten Bloody Palace yet. I don't think I S-ranked everything either, but I did beat DMD. Likewise for DMC4. I beat Bloody Palace and DMD. Was working on S ranks and Hell-and-Hell, but got distracted by RPGs and BlazBlue.
100% Ninja Gaiden Black. Beat Master Ninja and got all 50 Scarabs several times on various difficulties.
95+% in AC2. Did every story mission there is, but I'm missing 40 or so feathers. Was completely planning on getting them all, but started playing the Ezio sequels and more RPGs.
I have every flag and weapon for AC:B. Didn't get to Level 50 in multiplayer and I'm missing Extreme Variety. AC:R multiplayer threw me off.
Did everything in AC:R singleplayer and multiplayer except for prestige how ever many times is the maximum. Missing one Achievement for dropping a scaffolding on 5 people, but that's it.
100% Mass Effect 2. All Achievements for everything, DLC included. Haven't played it 6+ times yet though. If I do a new character I want to start from the beginning, but that will take a lifetime of play considering my other games.
I was on the way to 100% the Metroid Prime games, Fusion, and Zero Mission, but kinda gave up on it in the end.