I'm assuming this is for games that haven't been released yet? If that's the case, these are mine:
The Last Guardian, a.k.a. "The Number 1 Reason I Got a PS3." I can't really elaborate too much beyond that, but it looks to be another awesome game from Team Ico, but it'll probably be overlooked by most everyone.
Fallout: New Vegas: Yeah, I'll toss in my chips with this one, too. I loved 3, but I'm curious to see how some of the original series' creators will handle the move to the open-world 3D environments.
Other than that, not looking forward to anything (unless word were to come of Mega Man Legends 3 or Shenmue 3, then that would be great.)