In Fallout 3, using VATS to shoot a Super Mutant Overlord's weapon right out of his hands, crippling one of his legs with the shotgun, then turning him to dust with the Alien Blaster.
Personally I like to leave the biotic and tech stuff to my team. I've always wondered why I picked Mass Effect, to shoot.MazzaTheFirst said:*Spoiler free*
Mass Effect 2, still spoiler free, set to insanity difficulty. Spent about an hour trying to get through one room. After the billionth loading screen the first enemy starts attacking me as usual. But this time was different. I defiantly yelled, "No!" and proceeded to Rambo through the complex smiting down my foes with a volley of biotic and tech abilities. Finishing that level made me feel unstoppable. I still dread the later parts of the game though, they are gonna be hard. >.<
Also, Team Fortress 2 (Because that game has never been mentioned here [/sarcasm]) My little old self as a medic against six enemies, mostly demomen and scouts. Killed all but the seventh scout who ambushed me afterward. People seemed to be a little impressed but I was pretty lucky with abusing spawn doors and crits. Still felt good though.