There are a lot of great human villains, but lets take some time for the non-human villains. Mine are:
Grigori, from Dragon's Dogma. Smaug from The Hobbit could belong here, but I find him too generic evil dragon for me. Grigori is far less obviously evil and his motives less certain at the outset as he does create the one person that can kill him.
For a villain that is more even-handed in their portrayal, Hokmuto and Femuto from Godzilla 2014. These creatures are only out for themselves in a world that doesn't want them. Their only goal is to breed and eat, after all, they are animals.
Grigori, from Dragon's Dogma. Smaug from The Hobbit could belong here, but I find him too generic evil dragon for me. Grigori is far less obviously evil and his motives less certain at the outset as he does create the one person that can kill him.
For a villain that is more even-handed in their portrayal, Hokmuto and Femuto from Godzilla 2014. These creatures are only out for themselves in a world that doesn't want them. Their only goal is to breed and eat, after all, they are animals.